Kendriya Vidyalaya, CECRI Campus , Karaikudi made her humble beginning on 17th August, 1976, as a branch Vidyalaya of Kendriya Vidyalaya , Madurai with a population of 94 students. The Vidyalaya attained the independent status and started the classes upto VI with strength of 163 students. She had been growing steadily in her staggering strides, amidst many-sided difficulties and shortcomings and rose to the position of a full pledged Kendriya Vidyalaya of classes upto X in the year 1981- 82 and XII class(Science Stream) in the year of 2007-2008. Central Electro Chemical Research Institute being the sponsoring authority had committed to run the vidyalaya with all amenities, equipments, play fields and such other vidyalaya needs while the Kendriya Vidyalaya Sangathan, New Delhi bear the responsibility of providing the teaching personal and the Pay and allowances to the staff.

Kendriya Vidyalaya, CECRI Campus, Karaikudi has been given the sanitation Rating GREEN under National School Sanitation Initiative by Minister of Urban Development, Government of India

The Kendriya Vidyalaya School campus is located in Karaikudi's pollution-free education corridor. The enelopment and an good designed curriculum.
Classrooms are spaciously designed to seat 40 students, and are equipped with play areas for pre-school, projection systems, computer facilities. The integrated sports complex comprises of an indoor-stadium and an outdoor track and field stadium. The well-equipped amphitheatre has a seating capacity of over 200.