The GIDC started the Industrial Estate Vapi, in 1968. As the industries became functional and the entrepreneurs and technical people started arriving, it was imperative to start an English Medium School, to cater to the educational needs of wards of these people. The need for a good school in Vapi coincided with the dream of Mrs. Sandra Shroff, of United Phosphorus Ltd., to set up an ideal school. With the strong support of Shri Rajjubhai Shroff, her husband and some of their friends, Mrs. Shroff took the lead and established Gnyan Dham School in 1972 under the aegis of the Gnyan Dham Vapi Charitable Trust (G.D.V.C.T.). The school was affiliated with Gujarat State Education Board (G.S.E.B.). The land for the school was allotted by the G.I.D.C. United Phosphorus Ltd. gave financial support in constructing the school building. Additional financial support was provided by donations from reputed industries and individuals.

In 1989, the School was affiliated to the Central Board of Secondary Education (C.B.S.E.), New Delhi. In 2000, the name of the School was amended to 'Smt. Sandraben Shroff Gnyan Dham School', as a mark of respect and admiration, for Mrs. Shroff?s involvement and enormous contribution in nurturing the school to its present status.